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In the Fremantle Diabetes Study, 38%% of cognitively 'normal' individuals, 45%% of people with reduced cognitive function, and 75%% of people with frank dementia had evidence of coexisting PAD [ 14].
Therefore, we recently demonstrated that fatigue was also correlated with reduced cognitive function in elementary and junior high school students.
Coast et al. [ 87] and Hulme [ 88] have advocated for interviewer help to complete the instrument when used among the very elderly and those with reduced cognitive function.
Suglia et al. (2008) reported that exposure to black carbon was associated with reduced cognitive function scores in 8- to 11-year-old children.
In addition, one may question whether these participants with reduced cognitive function at follow-up could give valid responses to the HADS and the WHOQOL-BREF.
In the present study, comorbidities associated with worse cancer-specific mortality primarily included diseases associated with organ failure and with reduced cognitive function.
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She presented with reduced cognitive functions, diffuse and severe livedo reticularis, severe myalgias and mild stiffness.
This is consistent with the research of Rafnsson et al. (20), who reported that individuals with peripheral arterial disease had worse cognitive function than healthy controls, and with the research of Hanon et al. (21), who reported a significant relationship of reduced cognitive function and arteriosclerosis (based on PWV) in 308 elderly patients.
In humans, subclinical hypothyroidism during fetal development has been shown to result in reduced cognitive function [ 8].
Previous studies have found reduced cognitive function with reduced neuronal activation following sleep loss in the PFC [ 9] and indicated that sleep loss induces alteration in synaptic plasticity and membrane excitability in the cortex [ 10], which might be modulated by dopaminergic system.
In a group of type 1 diabetic patients with early exposure to SH, we have previously reported EEG abnormalities [ 2] and reduced cognition [ 1] in childhood and persistently reduced cognitive function after 16 years of follow-up [ 7].
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