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However, LOFS is more refined than the Balducci score, as its semi-continuous scoring system is in line with recent evolution in the geriatric research field, where frailty is more and more seen as a continuous event (cumulative deficit model) [ 4].
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Moreover, with the recent evolution of structured biomaterials possessing physical and mechanical actuating elements, it is feasible to manufacture material systems that can impose variable physical constraints on cell functions and generate tissue realistic patterns.
This article provides a historical context together with the recent evolution of the organ/organotypic culture, chick limb organ culture and chorioallantoic membrane models and the application of innovative imaging techniques to further our understanding of skeletal tissue regeneration.
This issue must be discussed in line with the recent evolution of ideas and policies in terms of fluid administration in critically ill patients.
These findings suggest an expanded ecological range that, intriguingly, is consistent with the recent evolution in North American P. cespitosum populations of adaptive plasticity in response to high light.
The concave and sharp dose gradients created by IMRT of course are less forgiving than conventional RT plans in terms of treatment uncertainties and require daily accurate positioning, which can be obtained with the recent evolution in IGRT.
Given these considerations and the fact that many of the gene losses are associated with the relatively recent evolution of parasites (Fig. 13, 14, 15, 16, 17, 18, 19, 20), it seems likely that the early phase of the evolution of prokaryotes (which is the same as the evolution of life itself prior to the emergence of eukaryotes) had been dominated by HGT.
On the basis of our finding of multiple haplotypes with extreme REHH and at relatively low frequencies (i.e. all below 37%), our results appear to be more consistent with a mode of recent evolution characterized by multiple soft sweeps as opposed to single hard sweeps [ 16].They also suggest that the patterns of differentiation and REHH are not uniform and homogenous across all Eurasians.
However, there is another aspect to this art that often escapes attention, but which is now providing scientists with fresh insights into our recent evolution.
Hence, this study has identified STRs likely to be involved in the expression of genes associated with particular disease phenotypes and recent evolution of the human genome.
Now, molecular evolutionary studies, including those investigating cryptic variance, produce evidence that precisely mirror Darwin's observation at the molecular level: loci of substitutions between related species (recent evolution) are associated with SNPs (present variance) [ 166- 168, 170- 172] and with regions of adaptive evolution [ 182].
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