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Furthermore, prenatal diagnosis by biochemical analysis is only possible in chorionic villus cells and is effective with qualitative alterations but unsuitable for quantitative defects and delays time of diagnosis by 2 4 weeks compared with genetic analysis.
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These results suggest that acquisition of enhanced tumor aggressivity can be associated with profound qualitative alterations in ribosomal control, leading to reduced quality control of translation in cancer cells Nucleoli were among the first structures of eucaryotic cell nuclei to have been identified and functionally characterized.
Fibrosis is associated with quantitative and qualitative alterations of collagen deposition within the subepithelial layer of the oral mucosa.
These results show that the acquisition of an aggressive tumor phenotype is associated with profound quantitative and qualitative alterations in ribosomal biogenesis and function.
Only qualitative alterations were found with a sensitivity similar to that obtained using classical molecular techniques for screening punctual mutations.
We show that increased tumorigenicity was associated with modifications of nucleolar morphology and profound quantitative and qualitative alterations in ribosomal biogenesis and function.
Our findings concerning exposure of PC12 cells to different hypergravity values showed no qualitative alterations of cytoskeletal f-actin localization with respect to the controls.
SNPs located at these regions may induce quantitative and qualitative alterations in protein expression and thus correlates with some diseases, which are often referred to as functional polymorphism [ 9].
Neither quantitative nor qualitative alterations of ras-p21 expression were found to correlate with tumour progression [ 20].
Qualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes.
Also unlike vitamin B6 deficiency, qualitative alterations in the cortical bone mineral composition were observed.
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