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This view is confirmed by the strongly decreased microsomal level of PE and the significant reduction of Lro1p activity in cki1∆dpl1∆eki1∆ which is associated with profound reduction of TAG (see Table 3 and Fig. 3).
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Torpor is associated with a profound reduction of energy expenditure to as little as 3% of the euthermic rates at ambient temperature [1].
It has been extensively demonstrated that patients with DM have a profound reduction of EPCs levels in peripheral blood, which has been correlated with the high cardiovascular morbidity and mortality associated with diabetes [ 10, 26].
Furthermore, treatment of HeLa cells with dynasore resulted in a profound reduction of tubular endocytosis in HeLa cells and a redistribution of GRAF1 to basally located puncta.
Compared with control iPSC-CMs, a profound reduction of the L-type Ca2+ current was found in DMD iPS1 CMs (Fig. 5A), consistent with previous observations from mdx mice (Koenig et al., 2012).
In line, we observed that patients with uncomplicated type 1 diabetes have a profound reduction of endothelial glycocalyx, which was associated with increased plasma hyaluronan and hyaluronidase levels [ 8].
44 A recent network meta-analysis reported a profound reduction of stent thrombosis with everolimus eluting stents compared not only with other drug eluting stents but also with bare metal stents 45 a finding that is supported by experimental evidence of antithrombotic properties of everolimus eluting stents.
It is now understood that profound reduction of NO occurs with aging so that a 40 year old adult may only produce half as much NO as a 20 year old [ 31- 33].
In our experiments, the profound reduction of TAMs was associated with complete tumor regression [36].
Conversely, removal of this contribution with a single inhibitor may lead to a profound reduction of activation.
Weekly measurement of the tumour volume over a period of 4 weeks revealed a profound reduction of tumour growth in animals inocculated with switched on Jurkat-TRAIL cells.
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