Hingorani and coworkers [ 59] also demonstrated that a mild inflammatory response, such as that generated by Salmonella typhi vaccine, is associated with temporary but profound dysfunction of arterial endothelium in both resistance and conduit vessels following application of both physical and pharmacological dilator stimuli.
It is well known that the development of an inflammatory environment in the vasculature is followed by a clear impairment of endothelial function; indeed, acute systemic inflammation with Salmonella typhi vaccine produces a temporary but profound dysfunction of human arterial endothelium in both resistance and conduit vessels, which is related to cytokine production [ 29, 30].
ChiCTR-TRC-10000835. Traumatic brain injury (TBI) is associated with profound immunological dysfunction.
Using measurements of ScvO2, it is possible to identify patients with profound global myocardial dysfunction who are hence at risk of impaired perfusion.
Erectile dysfunction (ED) is a prevalent male sexual dysfunction with profound adverse effects on the physical and the psychosocial health of men and, subsequently, on their partners.
In contrast, the tracer was retained in the kidney over approx. 15 min in the Ins2+/−AkitaJ mice, consistent with a profound tubular dysfunction.
Traumatic brain injury (TBI) is associated with a profound immunological dysfunction manifested by a severe shift from T-helper type 1 (to1) T-helperper type 2 (Th2) response.
Patients with mutations in USH1C exhibit the classic USH1 pathology, with profound congenital hearing impairment, vestibular dysfunction, and clinically appreciable retinal degeneration in childhood or early adolescence.
HIV infection is associated with profound cellular alterations including immune dysfunctions and neurological and cardiac complications.
Here, we report the identification of LIG4 mutations in 11 patients with profound global growth failure, expanding the phenotypic spectrum associated with dysfunction of the ligase IV enzyme.
