However, there has been a rush by many research teams to explore easily accessible databases to refute or confirm the early findings, though frequently with perpetuation of serious methodological flaws.
On the other hand, acute or persistent oxidative stress, which has been hypothesized in the pathogenesis of IPF, leads to an increase of intracellular ROS, damage of the lysosomal membrane with intracellular release of potent hydrolases, dysregulation of autophagy with perpetuation of the oxidative injury, and initiation of a vicious circle that leads to apoptotic cell death.
For some advocates of the work ethic, the route to health and happiness lies with the perpetuation of work, not with its reduction.
In March 1976, this coalition of open-housing advocates, in concert with the city of Englewood, N.J., filed a class action in federal court in Newark, charging most of Bergen County's real estate brokers with the perpetuation of a racially segregated housing market.
"It is my only way of dealing with the perpetuation of the human race," she explains.
We are confronted with a perpetuation of disparities between and within nations, a worsening of poverty, hunger, ill health and illiteracy, and the continuing deterioration of the ecosystems on which we depend for our well-being.
DNMT1 is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney [7].
Hypermethylation of RASAL1 was associated with the perpetuation of fibroblast activation and fibrogenesis in the liver.
Furthermore, hypoxia also inhibits adipogenic differentiation, which favors adipocyte enlargement, with the perpetuation of the situation [ 40].
Hypermethylation of RASAL1, encoding an inhibitor of the Ras protein, is associated with the perpetuation of fibroblast activation and experimental renal fibrosis (Bechtel et al., 2010).
Suffering trauma predisposes alcohol dependence, which in turn predisposes new traumas and violent events, in the same individual and also within families, for generations, collaborating with the perpetuation of a violent society.
