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The altered expression of PERP highlighted this apoptosis-specific target of p53 as a possible contributor to apoptosis in uveal melanoma with PERP downregulation being particularly relevant to the aggressive (monosomy 3) type of uveal melanoma.
We also confirmed microarray results with Perp, Nedd4 and Uqcrc2, genes associated with apoptosis, ubiquitin-mediated proteolysis, and mitochondria organization, respectively.
The population of such chelated conformers is significant for 2,6-difluorobenzyl alcohols with the help of a CαH⋅⋅⋅F interaction, but in competition with perp conformers in which two CαH⋅⋅⋅F interactions occur.
Although patient outcome has not yet been correlated with Perp expression levels in human breast cancer, human Perp (also known as THW) is downregulated in human mammary carcinoma cell lines compared with nonmalignant mammary epithelium [ 49].
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"She's dealing with perps, and I'm trying to keep them from becoming perps," said Dr. Ante, who has many students who live in group or foster homes.
CLEM of HeLa cells transfected with PERP-C and control oligos (left panels) or Ki-67 oligonucleotides (right panels).
Interestingly, however, on close investigation of virgin 8-week-old mice with Perp-deficient transplants, we discovered a significantly increased number of abnormal nodules or foci, especially at the bifurcation points of branching ducts, compared with wild-type counterparts.
As soon as a suspected shoplifter leaves the store they're on the horn providing fellow-retailers with the perp's description and modus operandi.
Wall Street scandals, replete with the perp walks of the formerly powerful, have been well covered in the past, but Ms. Stewart's gender, history and refusal to cut a deal set her apart.
For almost two decades, "Cops" has dutifully documented police officers as they contend with backyard perp chases, domestic disputes and the occasional moving violation committed by a woman in a bikini.
The unpopular rich, on the other hand, are the ones who remain largely anonymous — until they burst onto the scene with a perp walk (L. Dennis Kozlowski or Ken Lay), or they are garroted by the press for their ridiculous pay (Robert Nardelli of Home Depot, Dick Grasso of the New York Stock Exchange).
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Justyna Jupowicz-Kozak
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