Although faced with many challenges, novel methodologies such as exosome-based delivery systems provide sufficient evidence in support of the continued efforts to develop improved systems of delivery and target-specificity, desired in vivo stability, reduced side- and off-target effects for miRNA-based therapeutic approaches [87 89].
The combined efforts of many groups in the field, with the help of novel methodologies and new model organisms, are facilitating a much deeper understanding of this complex assembly.
Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors.
In this study membrane lipids of intact viruses have been analysed by MALDI-TOF/MS with a novel methodology avoiding lipid extraction and separation steps.
We experimented with a novel methodology to test the effect of an activity, 'field trip', on individual researchers' in a Murray-Darling Basin Research Program, Australia.
Hence the second objective of the paper is to provide researchers with a novel methodology for the design of a dataset on pensioners by making the CSWL more representative of the population in terms of type of pension, gender, and age, and by trying to miss as few pension records as possible so as not to overlook diversity in working lives.
However, the significant progress made in the incorporation of unnatural amino acids into proteins together with the continuous advent of novel methodologies for their modification (e.g. metal-mediated strategies) has opened up new opportunities to explore and exploit bioorthogonal transformations using these reactive handles.
Comparative studies allow validation of novel methodologies by comparison with established 'so-called standard' techniques.
Prognostic indices that integrate clinical, histologic, and molecular parameters will need to be developed and validated in conjunction with novel bioinformatic methodologies (i.e. artificial intelligence) to aid clinical decision-making.
Further research that utilizes novel methodologies and is directed at examining navigation interventions for men with prostate cancer who lack VA support is needed.
