A thorough characterization of the Bcl-2 BH3 mice as compared with mice over-expressing Bcl-2 alone revealed no substantial differences.
To directly assess the contribution of apoptosis to OPMD and test the relevance of apoptosis in vivo, we have crossbred A17 mice with mice that over-express BCL2 (B-cell CLL/lymphoma 2).
It's an attractively drawn setting, with plenty of mouse-over information about the details of life in such a camp; what it isn't, however, is either easy to fathom or to interact with.
In contrast, studies with transgenic mice over-expressing VEGF-C and VEGF-D under keratinocyte or pancreas specific promoters have demonstrated the role of these growth factors mainly in lymphangiogenesis [20] [22].
To address the contribution of astroglial NF-κB and, more generally, the contribution of astrocytosis to ALS onset and progression, we generated a mouse line expressing an IκBα-DR (IκBαAA) in astrocytes only, under control of the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter, and crossbred them with transgenic mice over-expressing ALS-typical mutant SOD1G93A.
Finally, each cell in the heat map is associated with a mouse-over event that pops-up tooltips showing the data-value of the cell.
Each tab is explained in detail with a mouse-over tooltip and more information can be found within the help pages, where the data sources are also referenced.
The Omics Viewer [20] in BioCyc [21] implements this feature with pop-ups upon mouse-over action.
Every day Matthew flies a Global Hawk remotely from his computer console, steering it with his mouse over a militarily significant part of the globe, from where the aircraft's powerful sensors stream back precision images of enemy targets to air force headquarters.
In 129SVE animals, the time spent with another mouse over an object was significant, but only a trend was seen for an unfamiliar mouse versus a familiar one.
