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Distress appears to be malleable, even with modest intervention, if it is addressed regularly and directly (19).
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More research is needed regarding how to achieve such high uptake of EBF among HIV-infected women in programmatic settings but our data are encouraging that EBF can be achieved among a high proportion of HIV-infected women with a modest intervention in the context of clinical research.
Proposals ranged from "modest intervention" to reconstruction work "on an epic scale".
But real success with these and dozens of other more modest interventions rests with persistent execution, often involving many painstaking steps.
Even modest interventions could start to close this gap.
Even modest interventions can have lasting impact.
Our conclusions are also consistent with those of Goldie et al. [ 52] who argued that even adherence interventions with modest effects may be cost effective, and Freedberg et al. [ 53] who showed that a nurse-led adherence intervention was cost-effective with a cost per QALY of $14,100 compared to usual care.
For example, some interventions with modest clinical benefits may be highly valued by patients and families yet expensive for the health-care system (e.g., enzyme replacement therapy).
Moreover, most exercise interventions included very low subject numbers, limited study designs and short-term intervention periods with modest or no follow-up periods.
Earlier studies indicate that midwife-led birth settings are associated with modest benefits, including reduced medical interventions and increased maternal satisfaction.
Psychosocial interventions were associated with modest improvements in A1C (standardized mean difference −0.29 [95% CI −0.37 to −0.21], I = 45%) (supplemental Fig. 2) and smaller improvements in mental health (−0.16, −0.25 to −0.07, I = 56%) (supplemental Fig. 3).
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