Mutations within human MRP2 result in an inactive MRP2 protein in the canalicular membrane as observed in Dubin-Johnson syndrome (DJS), a hereditary disorder with modest elevation of serum conjugated albumin [52], [66], [67].
In later studies of mouse islets with luciferase-expressing α-cells, there were modest elevations of ATP in response to 15 20 mM glucose (11, 14) concentrations, much higher than the 7 8 mM that maximally inhibits secretion (20, 24).
In addition, modest elevations of liver enzymes were noted with ALAT of 57 U/L as well as normal tests of renal function.
Samples from rats #s 407, 416 and 420 were dosed with 1500 mg/kg acetaminophen for either 18 or 24 hrs durations, but had only modest elevations of ALT and AST.
Whether there are subclinical effects of even modest elevations of maternal IAP on the fetus is completely unknown.
To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations.
Recently it has been observed that modest elevations of hCG of pituitary origin can also occur of a part of normal physiology in post menopausal women in parallel with the high levels of LH and FSH produced [ 6].
Modest elevations of plasma UCB in newborns and adults are considered beneficial owing to the antioxidant properties of bilirubin (Doré and Snyder, 1999; Doré et al., 1999).
In a representative sample of U.S. adults who participated in NHANES 1999 2004, cadmium levels in blood, but not in urine, were associated with a modest elevation of blood pressure levels.
Of particular interest is the significant (p<0.05) but modest elevation of AEA in subjects with the FAAH 385 mutant A alleles (Figure 1), since AEA activates the CB1 receptor and has the potential to stimulate appetite and feeding behavior as well as modulate several metabolic functions including fatty acid metabolism and contributes to diet-induced obesity [12], [16].
