The adverse events with the highest incidence was mild vomiting, which was higher in AS+AQ and AS+SP than in the AL arm (P < 0.001), followed by abdominal pain and headaches (Table 4), which was similar in the three arms.
Barium fluoroscopic study of a 37-year-old male from Ecuador presenting with intermittent episodes of right lower quadrant pain, mild vomiting, diarrhoea, and fever.
There were 11 cases of nausea and mild vomiting, 2 cases of diarrhoea with some dehydration, 9 cases of diarrhoea with no dehydration, 1 rash without itch, and 1 case of tremors.
The least significant difference post-hoc test revealed that pregnant women with mild nausea and vomiting had significantly lower stress than did pregnant women with severe nausea and vomiting.
Overall PLX4032 was well tolerated with mild nausea and vomiting, skin rash and diarrhoea, but 21% of the patients on active doses developed cutaneous neoplasms, including keratoacanthoma (KA), low-grade squamous cell carcinoma (SCC) and verrucal-like lesions.
Although in the phase 3 trial, mTORis were associated with mild-to-moderate vomiting and diarrhoea, no significant difference in the increase in SCr was observed between the everolimus and placebo groups of patients [ 98].
Toxigenic V. cholerae O1 was isolated in three cases: two were in students who presented with mild diarrhea with no history of vomiting, fever, and no hospitalization, and the third case patient was hospitalized for severe diarrhea.
There were some episodes of headache associated with symptoms of migraine such as nausea, vomiting, sensitivity to light and sound, but with mild frequency (every 12 15 days).
In HuCV-positive cases, 83% were associated with vomiting, 32% with fever, 24% with mild dehydration, and 2% with severe dehydration.
Patients with mild to moderate toxicity experienced symptoms such as insomnia, anxiety, nausea, vomiting, palpitations, dystonia and urinary retention.
