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Balloon dilatation in apneic pause was performed using 20 mm balloon with mild effect).
GW182 contains two repression domains, which trigger translational repression with mild effect on mRNA decay, and multiple glycine/tryptophan repeats essential for formation and maintaining stability of the multiprotein RISC complex [ 44].
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Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
Some mutations in the fly with mild effects on TOR activity cause small or negligible alterations in animal size, but significant alterations in metabolic parameters such as total body lipid levels [12], [13].
When administered sublingually, the threshold for the onset of hallucinogenic effects reportedly is about 100 250 μg, with mild effects after 250 450 μg, strong after 450 800 μg, and very strong over 800 μg [ 12].
A common assumption in the disease genetics literature is that disease manifestation statistically associates with decreased fitness, and therefore, that (i) disease susceptibility alleles are deleterious and (ii) alleles with more severe effects on disease susceptibility tend to be more deleterious to fitness than those with mild effects (Eyre-Walker 2010; Simons et al. 2013).
It is now believed that many rare but penetrant mutations contribute to ASDs and SCZD, and that hundreds of common variants with mild effects are shared by SCZD and bipolar disorder (O'Donovan et al., 2008; Walsh et al., 2008; Moskvina et al., 2009).
This is in line with its described involvement in other inflammatory diseases, but with milder effect in the case of arthritis.
The last case produce a single ectopic beat without any repetition and with a mild effect in the cardiac muscle.
In contrast, a Rap1A A59T mutant showed opposite characteristics with a mild effect on HT1080 proliferation but a clearly enhanced effect in the flat revertant assay.
Mutation of K70 did not significantly affect the genomic distribution of PSIP1 in correspondence with the mild effect on the affinity for nucleosomes of this mutant in EMSA.
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