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The relative inefficacy of etanercept in the Ncf1 −/− mice, along with the marked effectiveness of anti-IL-1β antibody in decreasing the joint thickness in these mice, suggests that IL-1β, which is significantly higher in the inflammatory joints of Ncf1 −/− mice (Fig. 3), plays an important role in enhancing arthritis severity in these mice.
Anticholinergics have been associated with constipation, but in this study, drugs with marked anticholinergic effects were not associated with the effectiveness of laxatives.
One gibberellin is gibberellic acid (GA3), which is present in higher plants as well as in fungi; many related compounds have structural variations that correlate with marked differences in effectiveness.
Conclusion Most tumours were large with marked mass effect.
Muscular strength decreases but with marked individual variability.
Patients often present with marked hypercholesterolaemia.
Meanwhile, the Buseys were also courting investors, with marked success.
The temperature is generally hot, with marked variations between summer and winter.
The therapy outcome was positive, with marked symptom improvements.
Effective divisors on moduli spaces of rational curves with marked points.
Carcinoma of the lung with marked hyperamylasemia and elevated serum calcitonin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com