The onset of enhanced glaciation also coincided with a marked acceleration in exhumation across the orogenic wedge, accelerated backthrust motion, and a major shift in deformation away from the North American Yakutat terrane suture (Chugach St. Elias fault).
"The September survey represents the best set of monthly figures within the quarter, with a marked acceleration in construction activity and a pick-up in new orders and employment levels.
Consistent with this marked acceleration of disease, histological examination of pancreata showed a significantly more rapid progression from benign to aggressive/destructive insulitis in anti-GITR-treated NOD mice as compared to controls (figure 1B).
Such increase correlates with a marked acceleration in tumour progression, impacting on both the biology and histology of kidney carcinomas.
Bone mass increases throughout childhood with a marked acceleration during puberty, when estradiol serves to increase bone density and suppress bone remodeling, resulting in an increase in cortical thickness (Wang et al. 2004).
In imaginal discs, clonal overexpression of these factors together led to marked acceleration of the cell cycle and increased cell number (Neufeld et al, 1998).
In contrast to zaragozic acid and Ro48-807, a short treatment of wt cells with fluconazole induced a marked acceleration of Erg1 degradation.
In other mutants like L239W, I230W or M238W, the positive shift in the voltage dependence of activation is accompanied by a marked acceleration of channel deactivation with τdeact = 40±3 ms (n = 5), τdeact = 80±6 ms (n = 8) and τdeact = 89±12 ms (n = 9), respectively, in comparison to WT Kv7.1 (τdeact = 372±40 ms, n = 20) (Figure 3A and B).
A range of heteroatomic dienophiles (6 a– g) were explored (Table 8), with all reactions proceeding at room temperature in dichloromethane; this represents a marked acceleration compared to the carbon-based dienophiles studied previously, which generally required prolonged heating (1 24 h) to achieve good levels of conversion.
The study shows that some aspect of human activity does interact strongly with the climate on shorter time scales, and it may help explain the marked acceleration in global warming in recent decades, says Dian Seidel, a climatologist at NOAA not involved with the current study.
We have recently demonstrated that EE from birth determines a marked acceleration of visual system development, detectable at the functional level, with a precocious maturation of retinal and cortical acuities, and at the molecular level, with increased levels of BDNF in the retina and of BDNF and IGF-I in the visual cortex [2], [4], [32].
