Sentence examples for with low effects from inspiring English sources

Thus, technological advances have allowed for the identification of very rare causative mutations underlying Mendelian forms of disease through linkage analyses and of common variants with low effects contributing to the susceptibility of late-onset and 'sporadic' disorders through GWAS.

"Low dose" is variously taken to mean "doses lower than used normally in toxicity testing"; "doses that approach, or are equal to, those encountered by humans"; or "doses associated with low effects" (National Toxicology Program 2001; vom Saal and Hughes 2005).

Furthermore, the strategy was also applied for detecting UDG activity in HeLa cells lysate with low effect of cellular components.

In addition, the strategy was also applied for the analysis of UDG activity in HeLa cells lysate with low effect of cellular components.

Ultimately, the cumulative contribution of such mutations with low effect sizes may play a large role in causing the disease.

The most common switches were gain or loss of H3K27me3 coupled with low effect on gene expression.

Figure 3 (solid curve) shows the number of causal variants as a function of the heritability for the common-variant model with low effect-sizes.

The worse scenario regarding sample size is model B, the model of rare variants with low effect-sizes, where at least 125,000 cases and 125,000 controls are needed to discover approximately 1400 variants among the top 5000 SNPs.

A larger collection is necessary to map such genes with low effect.

Also, comparatively small studies with low effect sizes or rather broad confidence intervals were included in the meta-analysis.

The study was estimated to have an approximately 75% power to detect positive association of a SNP with low effect.