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Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with loci on chromosome 9q34.12 (TSC1) and chromosome 16p13.3 (TSC2).
Surface and volume operations are defined to support crystal and molecular model creation with loci and foci periodic surfaces.
A decade of genome-wide association studies and other genetic analyses have linked IBD with loci that implicate an aberrant immune response to the intestinal microbiota.
This data set also revealed traits associated with loci known to confer autoimmune susceptibility, providing mechanistic hypotheses linking immune traits with the etiology of disease.
We next examined the expression of genes associated with loci in these modules.
The Ne2 locus shows extremely tight genetic linkage with loci that confer effective rust fungus resistance [2], [25].
Overall these data show that CNCs have the capacity to make extensive interactions with loci on other chromosomes.
The data provide evidence that CNCs are capable of interacting with loci that are enriched for CNCs.
Indeed, Ne2 has risen considerably in frequency over, apparently due to tight linkage with loci that confer effective rust fungus resistance [2].
For example, highly repetitive genomic regions (hr) are known to be associated with loci of genome instability and divergence among baculoviruses [26].
Candidate gene list was also supplemented with loci involved in other cardiovascular diseases related to hypertension (myocardial infarction, coronary artery disease and stroke).
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