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To focus on features with large expression differences, there were 276 (32% of differentially expressed genes) features with a minimum of a 3-fold change expression difference between the sexes in at least one comparison.
Our results suggest that ratios are most commonly reduced among the genes with large expression ratios in the OneRA, thus likely to be differentially expressed.
Although both genes are similarly expressed in most tissues they are strikingly different in heart with LARGE expression being high and B4GAT1 being low.
Noticeably, this correlation is mainly due to genes with large expression differences between species.
Therefore, genes with large expression changes in the period studied should have a particular phylogenetic signature.
We detected regions with large expression of the UPEC antigen, particularly in the tubulointerstitial compartment in HeN kidneys (Fig. 2C).
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Sense and antisense miRNAs have been characterized as potential miRNA-miRNA interaction with larger expression divergence.
These results suggest that miRNA activity is not perfectly correlated with miRNA expression levels although the correlation might be stronger with larger expression changes.
For the NCI60 and DLBCL datasets, the top x percent of genes with largest expression variances were selected as feature genes.
As shown in Fig. 5c, clusters with larger variety tend to have higher entropy values while clusters with smaller variety show lower values, an observation which supports our claim that "dynamic" promoters often regulate genes with larger expression variety.
We selected the signature pathways that were significantly (FDR ⩽ 0.01, see the Materials and methods section for the details) enriched with the 10% top-ranked genes with largest expression variances based on the NCI60 dataset [18].
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