We proposed a novel pharmacovigilance problem for mining directional effects of high-order ADE-associated drug interactions, and developed a graphical mining approach to efficient discovery and effective visualization of the directional DDI patterns with large effect sizes.
The iCBT group was superior to waitlist, with large effect sizes at posttreatment (Hedges' g = 1.45).
The differences in use of the learning aids were statistically significant with large effect sizes.
The differences between the means of all three levels were significant with large effect sizes, measured with Cohen's d.
Results from 17 RCTs showed computerised TD-cCBT outperformed control conditions on all outcome measures at post-treatment, with large effect sizes for depression (g's=.84), and medium effect sizes for anxiety (g=.78) and QOL (g=.48).
Identified profiles significantly differ in terms of their use of learning platform and their levels of cognitive presence, with large effect sizes of 0.54 and 0.19 multivariate η2, respectively.
However, the positive results with large effect sizes alleviated potential type II errors caused by small sample size.
Patients with schizophrenia have pronounced impairments in general intelligence level (IQ), verbal memory and processing speed, with large effect sizes of 1.0 and higher [1] [7].
Although we did not have the power to detect very small effect sizes, especially after an adjustment for multiple testing, we did have the power to find associations with large effect sizes, as we did with tPA.
One possibility is that these genes might harbour rare variants with large effect sizes, which would not be well tagged with the common SNPs selected for investigation in the current study.
Therefore, significant correlations with large effect sizes were expected.
