Finding of hyperphosphorylated forms of hRad9 in the nucleus of cancer cells is in keeping with its function in ameliorating DNA instability, whereby it inadvertently assists tumor growth.
Gene lists may serve as queries to functional databases returning key-value pairs associating a gene with its function.
The enlarged pocket in ChsH1-ChsH2N makes it possible to accommodate steroid CoA thioesters as substrates, consistent with its function in cholesterol degradation in Mtb(12).
The generally electronegative character of the pore surface may be consistent with its function in conducting cations across the membrane.
Indeed, the quickest way to turn a gene discovery into a drug is to make an antibody that binds to the protein and interferes with its function.
Acute pericarditis may result in the formation of scar tissue that contracts around the heart and interferes with its function.
Consistent with its function as a transcriptional repressor13, overexpression of ZKSCAN3T153A, but not WT, abolished the effect of PLX4720 on autophagy lysosome regulation (Supplementary Fig. 4d f).
Anfinsen was able to ascertain how the ribonuclease molecule folds to form the characteristic three-dimensional structure that is compatible with its function.
This study, therefore, suggests a way of engineering a PpL-binding site on any scFv without interfering with its function.
This solution has been implemented in Ptolemy II and the goal of this poster is to familiarize users with its function.
Our results suggest that the properties of the fibrin network have evolved to protect mechanically loaded fibrin from degradation, consistent with its function in wound healing.
