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Although it is possible that intercellular mitochondrial transfer occurs after endosomal internalization, this particular mechanism does not seem to be involved with internalization of exogenous mitochondria.
In line with internalization theory, we argue that firm-level performance depends primarily on the characteristics of the companies' firm specific advantages (FSAs) rather than on their degree of multinationality.
The high affinity binding of the probes QE and bivQ to the CCK2R in combination with internalization and hence signal amplification is an important prerequisite for low dosage for the prospective detection of CCK2R-expressing tumours in the clinical application due to a high contrast between malignant and healthy tissue.
Agonists at MOP cause fast receptor internalization with internalization half-times 2 5 min (Fig. 1D).
Serial dilutions of freshly prepared synthetic Aβ42 were prepared by diluting the Aβ42 stock with internalization media.
This result was also confirmed with internalization studies using CAIX positive RCC cells sk-rc-52 at 37°C or on ice (Figure 5C).
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Thus, if our in vitro cytotoxicity data correctly predicts in vivo efficacy (which has yet to be determined), only a subpopulation of lymphoma patients would have tumours suitable for treatment with internalization-dependent anti-CD19 ADCs.
TCR recruitment to the center of the IS has been associated with productive signaling [5], [14] and with TCR internalization [13], [15].
Dox fluorescence was initially localized in endosomes (SI 3) consistent with cellular internalization via an endocytic process and with release of Dox at the acidic pH of endosomes.
Next, we investigated whether the downmodulation of CD32a with an effector-competent mAb was coupled with BDCA2 internalization.
More efficient display of EGF correlated with increased internalization, vector potency, and transduction efficiency (∼9%).
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