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Of these samples those with insufficient material for detailed histological assessment of renal damage and inflammation score (see below) were excluded.
Category 0 was designated for unsatisfactory specimens, with insufficient material for complete evaluation, defined microscopically as having less than 10 ductal epithelial cells.
For the single ER-negative grade 3 tumour with insufficient material available for cytokeratin analysis, the likelihood was calculated based on ER expression and grade (LR 2.95:1), as described previously [ 5].
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The possible reversal at high concentrations was not possible to assess with the human substituted analogues due to insufficient material, with the exception of IleA10Arg which showed a clear trend for a bell-shaped curve [the last point of Figure 5A is significantly higher than the nadir of the curve (p < 0.05)].
Our study underscores the difficulties in assessing paired primary and recurrent tumour specimens when analysis is performed in a retrospective fashion with 26% of specimens having insufficient material available for in situ hybridisation.
In the multivariable analyses, estradiol concentrations were log transformed and missing estradiol and CYP2D6 values due to insufficient material were imputed with population medians.
Tumour concentrations of NVP-BEZ235 were measured in all of the acute single-dose samples with the exception of OCIP19, where insufficient material was available due to their small size.
Shannon et al. [ 17] reported a diagnostic biopsy rate of 78%, with 22% nondiagnostic biopsies due to insufficient material or nonmalignant renal material.
Moreover, we excluded tissue blocks of mixed histology, or specimens with insufficient tumor material.
Three patients with insufficient biopsy material were excluded from the study, leaving a total of 424 patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com