It has been shown experimentally that CXL of thin corneas or of corneas with insufficient concentration of riboflavin, for instance due to too short exposure to the riboflavin eye drops to allow sufficient absorption, can cause endothelial cell damage [ 28, 32, 42].
Continuous imipenem infusion administered as 2 g over 24 hours guarantees more sufficient plasma concentrations when compared with a standard regimen (1 g every 8 hours) that is associated with insufficient trough concentrations.
Insufficient concentrations were associated with early measurements (< 72 h from the sepsis' onset) (p = 0.035) and creatinine clearance increase (p = 0.01).
The only variable significantly associated with insufficient drug concentrations was the creatinine clearance on the day of the therapeutic drug monitoring.
The percentage of patients with insufficient drug concentrations in the ECMO group was 18% (n = 2/11) at T2 and 36% (n = 4/11) at T3, compared to 0% (n = 0/11) and 9% (n = 1/11), respectively, in the control group.> -wrap-foot> extracorporealporeal membrane oxygenation; Vd, drug median volume of distribution; CL, drug clearance; AUC0 24, area under the curve of the first 24 hrs of therapy.
Accumulating evidence indicates that insufficient concentrations of circulating 25(OH D are associated with glucose intolerance, insulin resistance, metabolic syndrome, and increased risk for diabetes (2).
The sources of this incomplete recovery were insufficient concentrations of oxidant in the absorbate, the deterioration of absorbate with time, and improper absorber designs.
Insufficient concentration at the tumor site due to P-glycoprotein efflux coupled with cardiotoxicity, nephrotoxicity, myelosuppression, and topoisomerase II resistance are serious limitations of current DOX therapy (Patil et al. 2008).
Despite Alexander's efforts, then, there was insufficient concentration of Confederate fire on the objective.
This decrease in size in mammals has been observed in rodents [19], in humans at high altitude [20], [21], in patients with congenital heart disease with right to left cardiac shunt [22], and in infants with chronic lung disease with insufficient inspired O2 concentration [23].
