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Histological and immunohistological analysis also demonstrated a grossly normal anatomical structure of the mutant embryos before E11.5, along with insignificant alteration of dorsal forebrain markers, Pax6 and Pax3 (Supplementary Material, Fig. S2).
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However, expression analysis with the artificial spike and U91 alone yielded a statistically insignificant alteration in miR-96 expression in tumors in comparison with normal tissues (p > 0.05, Table 4).
However, exposure of CuO nanoparticles in barley seedlings exhibited insignificant alteration in the Fv/Fm ratio.
Dispersion analysis of 0.5-hour aqueous Cu 50 nanoparticle suspensions showed insignificant alteration in particle aggregates sizes (dav); slight growth of dav from 177 to 250 270 nm was observed with concentration increase.
At this stage, there is insignificant alteration in myocardial structure and function that could be clinically assessed.
It is not clear whether this pathology is the primary stage of AD or other tauopathy or merely an insignificant alteration related to ageing.
We reassessed apoptosis activities in the MDA-231 cell line post-BST2 induction and observed insignificant alteration in apoptosis by FACS.
This is manifested not only by a decreasing equilibrium module when AG concentration rises but also by insignificant alteration in relaxation time.
The resultant point-mutated recombinant proteins were analyzed by circular dichroism (CD) spectroscopy and showed only minor, insignificant alterations in the secondary structure (Supplemental Figure S1).
Insignificant alterations of serum total protein were observed in mice of groups 3, 4, and 5.
This might explain the insignificant alterations in the levels of spinophilin in the cerebellum.
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