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Stimulation of the cells with MBP resulted in a predominant Th1 response, with IFN-γ being the main cytokine secreted with elevating levels that correlated with increasing proliferation.
The cumulative expression of p53 protein is significantly associated with increasing proliferation activity.
Positive polySia expression was also associated with increasing proliferation by MIB-1 / Ki-67 (p = 0.007, Kruskall-Wallis test).
Although polySia was associated with better prognosis in univariate and multivariate analysis, it was also associated with increasing proliferation.
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Human embryonic palatal mesenchymal (HEPM) cells attached and proliferated on all scaffolds, as evidenced by fluorescent nuclear staining with Hoechst 33258 and the Alamar Blue™ assay, with increased proliferation observed on 80 20 PCL CaP scaffolds.
The use of biaxial bioreactor here allowed the maintenance of cellular viability beyond the limits of conventional diffusion, with increased proliferation and osteogenic differentiation both in vitro and in vivo, suggesting its utility for bone tissue engineering applications.
In other cell types, Jnk2 deficiency has been shown to correlate with increased proliferation [31].
Accordingly, together with increased proliferation during postnatal age, we observed markedly low levels of Cx43.
A high arginase activity correlates with increased proliferation of breast cancer [26], colon cancer [27] and kidney cell lines [28].
In BCCs, nuclear beta catenin staining, corresponding to pathway activation, has been observed and associated with increased proliferation [27], [28].
The PC has also recently been implicated in the regulation of cell cycle progression and, as a consequence, a lack of PC was associated with increased proliferation [1] [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com