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Since the mutator lesions become progressively enriched with increasing progress towards malignancy, any experimental technique which looks at average mutation frequency across many premalignant lesions might falsely conclude that a mutator mutation is a "late event".
With increasing progress and application of rational methods in engineering, SSF will achieve higher levels in standardisation and reproducibility in the future.
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Typical lower FDG metabolism was shown in the precuneus, posterior cingulate, and temporal and parietal cortex with progression to whole brain reductions with increasing disease progress in AD brains [50, 51].
The M-protein concentration time curves are similar in shape to tumour SLD time curves, with some patients appearing to progress with increasing M-protein concentrations after developing resistance, some patients responding to treatment with decreasing M-protein and some patients progressing directly from the start of the study.
We further hypothesise that these PrPd-initiated morphological changes progress with increasing PrPd accumulation to more complex hypertrophic structures and excess immune complex retention as demonstrated by Ig labelling.
Albuminuria occurs more commonly with increasing age and may progress to ESRD.
With increasing medical and technical progress, the demand for certainty increases, leading to a paradoxical intolerance of uncertainty in patients and doctors [ 8, 29].
Also, it remains unclear at what age such changes start to arise in the population and at what rate they subsequently progress with increasing age.
Osteoarthritis usually begins in the fourth decade of life and slowly progresses with increasing age.
Heterogeneous photocatalysis with TiO2 particulate has rapidly progressed with increasing interest in the photo-oxidative degradation of various organic contaminants.
Ultrastructural changes in the kidney of crucian carp progressed with increasing accumulated MCs and exposure times within 48 h post-injection, whereas renal ultrastructural recovery of crucian carp in the 50 μg MC-LReq.
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