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With increasing compound coverage, the fraction of scaffolds involved in both scaffold hopping and activity cliff formation significantly increased to more than 50%.
HaCaT cells were incubated with increasing compound concentrations (3.2 nM – 50 µM) for 24 h.
Also, with added noise, sigmaf changed more gradually with increasing compound sigma compared to the abrupt changes measured with noise free compounds.
STP decreased with increasing compound sigma, but the difference between spike responses induced by synchronized and unsynchronized compounds with identical EPSC kinetics was not significant (ANOVA: p>0.05, Figure 4D).
Decreasing desorption rate with increasing compound hydrophobicity is expected and has been documented previously (22).
The number of apoptotic cells increased with the time of incubation, and with increasing compound concentration.
Similar(54)
Generally, the dot product kernel results in larger similarity values with an increasing compound or fingerprint size.
The overall LY2140023 exposure-adjusted rate of seizures had decreased substantially with the increased compound exposure in the current 24-week HBBR study and in other ongoing studies.
After the addition of the α-Phellandrene and Nonanal visibly increased with increasing volatile compound concentration.
Total antioxidant capacity (TAC) of compounds increase with increasing concentration of compounds.
First, the test compound's concentration−response relationships were examined by incubating mGlu5-expressing cells with increasing concentrations of compound in the presence of a fixed suboptimal concentration of glutamate (EC20).
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