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By iteratively querying each respective dataset with over-lapping nucleotide seed region queries we were able to generate hypotheses regarding the degree of seed region conservation (i.e. elevated enrichment scores equate with increased conservation of that motif in the target transcript 3'UTRs).
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I is close to zero in the absence of nucleotide conservation with respect to the background, and increases with increasing conservation up to around two bit per sequence position.
In particular, the Piwi/Argonaute/Zwille (PAZ) domain of Dicer-2 (DCR-2) had the least amount of sequence similarity of any domain among species surveyed, with a trend of increased conservation in those species with amenable systemic RNAi.
In general there is a tendency of increased conservation at STAT1 sites with higher ChIP-seq occupation, and sites close to TSS display a still increased and positionally broader conservation profile.
Windows with Z>1 were considered to have increased conservation, those with Z<-1 were considered to have decreased conservation, and windows with 1>Z>-1 had intermediate conservation.
Remarkably, the increased conservation in modern rodents coincides with a stricter conservation of typical DNA elements in imprinted genes in the mouse than in the human, such as intronic CpG islands [ 31].
There is a trend of increasing conservation with increasing age of a locus, but this trend was not strong and was not consistent across all measures of diversity.
Whether it is possible to reduce endogenous zinc losses into the lumen in children with EE, or to increase conservation of endogenous zinc from the lumen by improving its bioavailability and hence recovery by absorption, is unknown.
In contrast, conservation of NOPs drastically decreased along with the increasing conservation ratio.
Thus, our study shows that the coupling of conservation compliance with subsidized crop insurance is an effective way to increase conservation practices, especially since farmers want to ensure stable revenues and maximize profits.
The world will need all these sources of supply, since even with increased energy conservation, economic growth, led by China and India, could well mean that the world will use 20percentt more oil a decade hence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com