Accordingly, folic acid-DNA tetra-Dox markedly increased the antitumor efficiency with increased apoptosis levels.
Conclusion: The two topoisomerase inhibitors were associated with increased apoptosis and dosedependent necrosis.
Myocardial infarction (MI) induces an inflammatory process that is associated with increased apoptosis in the limbic system of rats and the development of post-MI depressive symptoms.
The results obtained provide evidence of dose- and organ-specific differences induced by carbon ions compared to X-rays, with increased apoptosis in peripheral blood lymphocytes and thymocytes, but not spleen lymphocytes.
Specifically, functional experiments have revealed that these HDACs are pro-oncogenic, with increased apoptosis and reduced proliferation (Class I) or reduced angiogenesis and cell migration (Class II) following specific HDAC knockdown (Ellis et al., 2009).
Enhanced drug sensitivity was associated with increased apoptosis for all drug treatment combinations, compared to single agent treatments (Fig. 1C).
Reduced ena levels correlated with increased apoptosis, which could be rescued in the presence of p35, a general Caspase inhibitor.
Our finding is counter-intuitive since it has been found that miR-21 downregulation was associated with increased apoptosis and decreased cell proliferation [35].
Both hyperleptinemia and leptin-deficiency have been shown to be associated with increased apoptosis, DNA damage and mortality, suggesting a potential association between leptin signaling and aging-related DNA damage and premature death [23].
We found that diclofenac treatment (30 mg/kg/bw for 11 days) of mice inoculated with PANC02 cells, reduced the tumor weight by 60%, correlating with increased apoptosis of tumor cells.
Concomitant with increased apoptosis, the c-Rel silencing groups also have significantly reduced cell cycle progression, as enumerated by the percentage of cells in the S/G2/M phase.
