Ultimately, this scientific progress will benefit patients, enabling new classes of therapeutics to be formulated as dry powder aerosols with improved efficacy, reduced variability and side effects, and improved patient adherence.
For example, IgGs lacking core fucose have been shown to possess a drastically improved in vivo activity and thus have raised interest as next-generation mAbs with improved efficacy [54,58].
There is an urgent need for new agents with improved efficacy, safety, and compatibility with combination chemotherapies.
These structures provide mechanistic insights into the binding modes and the antagonistic effects of the drugs, which might facilitate the development of ETR ligands with improved efficacy.
These studies are crucial in the development of lipid-based gene delivery systems with improved efficacy.
This study aimed to develop a hybrid nanoparticle-based nicotine vaccine with improved efficacy.
In future studies, the presented data may aid in designing new therapies for PCa with improved efficacy.
In the former, new drugs with improved efficacy and reduced toxicity entered the clinic; in the latter, immune-checkpoint inhibition proved efficacious after chemoradiotherapy for stage III disease, but had disparate results in the frontline treatment of stage IV disease.
Yeast engineered to express biosynthetic pathways for fermentative production of these compounds will further enable investigation of the medicinal properties of these molecules and development of alkaloid-based drugs with improved efficacy and safety.
The results showed that application of herbicide-loaded nanoparticles could be used to reduce the use of herbicides with improved efficacy and environmental safety.
This review also offers insights into the novel molecular targets that enabled the development of new antiepileptic drugs with improved efficacy.
