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An application to the GWAS summary results of the Genetic Investigation of ANthropometric Traits (GIANT) consortium reveals rare and low-frequency variants associated with human height.
It is also significantly associated with human height [ 36].
A GWAS that included 183 727 individuals showed that the PPARD gene was associated with human height [ 39].
This represents a substantial increase over the of phenotypic variance explained by the ∼50 variants known to be associated with human height.
HMGA2 variants are associated with human height [ 41], body size in dogs [ 42] and horses [ 43], and meat quality and carcass traits in pigs [ 44].
Even though 40 genomic loci have been identified to be associated with human height, they only explain 5%% of the phenotypic variance (Visscher 2008).
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A region on BTA14 specific to Angus cattle harbours several genes including PLAG1 which has been associated with variation in human height [ 60], the stature of cattle [ 61] and with vertebrae number and back elongation in swine [ 21].
A ~75 kb selective sweep at a locus influencing stature in the horse is upstream of a transcription factor (LCORL) that is associated with variation in human height [ 19].
Finally, genetic variants in both the DOT1L (Sovio et al., 2009) and other OA susceptibility genes (Sanna et al., 2008) have also been associated with variations in human height, further supporting the involvement of factors that regulate bone growth in the disease.
"To study the history of human height with no funding and no real support in the field.
The experimental results show that the proposed method can predict the human height with a mean absolute error of only about 1.39 cm from ground truth data.
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