Finally, the association of the MTHFR variant with T2D was not observed in large-scale GWAS studies with huge sample sizes.
Today, schemes for the prevention of MTCT have reduced the risk to almost zero, so, in an interventional research setting, carefully designed studies, probably with huge sample sizes, will be needed to assess a modified risk of MTCT.
However, it has to be noticed that the increase of risk found by Koutros et al was very modest and could therefore be detected only by a study with a huge sample size, such as BPC3.
To demonstrate the superiority of intravenous versus oral PPI treatment, a trial with a huge sample size was required.
Of course, with such huge sample sizes, the difference turned out to be highly significant statistically (Kolmogorov Smirnov test, P = 4 × 10−37).
For example, it is hard to imagine how the recent explosion of genome-wide association studies, with their huge sample sizes, could have taken place without collaboration and data sharing.
At the mix the multitrack becomes like playing a huge sampler with hour-long samples".
One of the reasons preventing either private or public investors from funding clinical studies in this field is the small expected difference between experimental drugs and placebo in children with headache, which means a huge sample is to be enrolled to see such a small effect.
There really was no shame with sampling in this era -- throw a huge sample over some breaks and you have a rave hit.
In speaking with more than 50 couples, which admittedly doesn't constitute a huge sample, but nonetheless is a pretty significant number, we found a number of consistent themes running through their marriages.
