Exact(2)
Finally, the association of the MTHFR variant with T2D was not observed in large-scale GWAS studies with huge sample sizes.
Today, schemes for the prevention of MTCT have reduced the risk to almost zero, so, in an interventional research setting, carefully designed studies, probably with huge sample sizes, will be needed to assess a modified risk of MTCT.
Similar(58)
Of course, with such huge sample sizes, the difference turned out to be highly significant statistically (Kolmogorov Smirnov test, P = 4 × 10−37).
For example, it is hard to imagine how the recent explosion of genome-wide association studies, with their huge sample sizes, could have taken place without collaboration and data sharing.
Treating fires as independent observations would result in huge sample sizes.
The reason is that high IRR coefficients are mostly based on small sample sizes than low IRR coefficients, which are based mostly on huge sample sizes.
Detection of these additional novel variants will require huge sample sizes.
In epidemiological studies, one may need to assess huge sample sizes, e.g. thousands of cases.
Now we report both Pearson's andf Spearman's correlation coefficients, which, due to huge sample sizes, are all significantly different from zero, despite being rather small.
Despite huge sample sizes, results will be useful only if it is possible to derive harmonized measures of exposure, biomarkers, and outcomes.
On the other hand, prospective clinical trials would involve huge sample sizes, as for every disease a sufficient number of patients should be included.
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