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In addition, negligible cell death and physiological state changes of SW480 cells treated with highest dosage of PHPP-SMNPs were observed in Fig. 14b.
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Ghafari et al. (2014) reported an increase in compressive strength of UHPC with higher dosage of nano-silica (nS).
The present research was carried out to evaluate the properties of magnesium phosphate cement with high dosage of metakaolin (MK).
This research work was carried out to evaluate the properties of oil well cement with high dosage of metakaolin.
Synergism was most appreciable following treatment with high dosage of both agents and the administration of bortezomib 24 h after X-radiation (Table 1).
In order to reveal relationships among the detected variables in tilapia fillets treated with high dosage of MFESI, Pearson correlation coefficients were analyzed and showed in Table 7.
The phenotype appeared more severe when injected with higher dosage of MO1 (12 ng; 77%, N = 52) or MO2 (8 ng; 84%, N = 51; Fig. 5C and 5F).
The mice in the group with high dosage of Cisplatin exhibited strong gastrointestinal toxicity (diarrhea), systemic toxicity (piloerection and lethargy), and a consistent decline in body weight.
The studies related with high dosage of oral administration of MSM showed the upregulated levels of MSM in blood which indicating the ability of MSM to diffuse in blood even in high concentration [ 24, 25].
Our observations corroborate prior studies showing a decrease in urinary levels of C-terminal telopeptide of type II collagen (CTX-II) and N-terminal telopeptide of type I collagen (NTX-I) with higher dosage of risedronate over time [ 34, 35].
When reproduced in vitro, the higher gemcitabine and SQ-gem concentrations and lower isoCA-4 concentrations, provided by the treatment with the nanocomposites, induced the efficient killing of both cancer cells and endothelial cells, whereas lower gemcitabine concentrations, even with higher dosage of isoCA-4, resulting from free drug treatment, failed to kill cancer cells.
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