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Table 2 reports the top 10 TFBS-ID with highest differentiation for all three populations.
Pairwise differentiation among the lake populations ranged from 0.0092 – 0.0702 with highest differentiation between populations of Globsowsee and Döllnsee and lowest between Schulzensee and Döllnsee.
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In addition, 13 subpopulations were observed in maize germplasm, 85 genetic regions with higher differentiation between TS and temperate maize germplasm, 197 highly differentiated regions between different subpopulation pairs, which contained some FT- related QTNs/QTLs/genes supported by GWAS and linkage analysis, and these regions were expected to play important roles in maize adaptation.
To investigate the biological effect of ALS-causing genetic mutations, we generated motor neurons from SOD1 +/A272C iPSCs and corresponding isogenic controls using a modified protocol with high differentiation efficiency (Qu et al., 2014; Maury et al., 2015) (Fig. 3A).
These tumors were characterized with high differentiation grade [33].
However, in contrast to these findings, the expression of this protein was associated with high differentiation.
We also evaluated if this protocol would support hepatic differentiation of adult cell types with higher differentiation potential, such as rat multipotent adult progenitor cells (rMAPC).
More than 80% of tumours with high differentiation grade showed overexpression of COX-2.
The so-called skin-derived progenitors are another kind of skin cells with high differentiation potential capable of hepatogenic differentiation.
Furthermore, the progression into the –16q state has been associated with high differentiation and good prognosis (Roylance et al., 1999).
The ESCC with moderate differentiation had a lower frequency of RASSF1A methylation than in those with higher differentiation (OR=0.28, 95% CI=0.12 0.69) (Table 3).
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