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We recently reported a piperidine carbamate, JZL184, that inhibits MAGL with high potency and selectivity.
Pharmacological agents that inhibit system xc activity with high potency have long been sought, but have remained elusive.
Huang, S. M. et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
These data demonstrate that symmetrical bis-tertiary amines are unique CXCR4 inhibitors with high potency.
The results guide to design new chemical entities with high potency.
Both 38 and 52 are full agonists with high potency at the D3 receptor in a D3 functional assay.
The results indicated that the studied compounds inhibited Chk2 activity with high potency (IC50 = 5.56 nM - 46.20 nM).
These results clearly provide useful insight in the design of new PI3Kβ inhibitors with high potency and selectivity.
These results would be beneficial to the designing of novel anti-TB drugs with high potency and selectivity.
The present study provides an approach to design siRNAs with high potency against a virus-specific target gene.
Finasteride and epristeride both inhibit 5α-reductase with high potency via competitive and non-competitive mechanism, respectively.
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