Exact(2)
A smaller study of the psychological adjustment of cancer patients with high performance status undergoing radiotherapy in Belgium and Turkey showed that Belgian patients experienced less psychological distress than Turkish patients before starting radiotherapy (Erbil et al, 1996).
Therefore, the results in the RCTs that included a large proportion of patients with high performance status may not be representative, and further research assessing the performance of such combination treatments in a more heterogeneous population in terms of performance status is needed.
Similar(58)
Inpatients and patients with poorer performance status scored higher on the MSAS-Ch subscale and total scores than outpatients and patients with higher performance status (P < 0.05).
The observed small study effect in the current analysis may also be due to such a true heterogeneity (Higgings, 2008), as a short-term benefit from chemotherapy is more likely in patients with high-performance status for tolerating toxicity of the treatment and such patients are more likely to be included in small, early phase clinical trials in the development of new treatment regimens.
First, we hypothesized that patients with a high performance status (Karnofsky performance scale [KPS] score > 70) would report lower levels of symptoms and a better QOL than patients with a low performance status (KPS score ≤ 70).
In addition to the small sample sizes in the current studies, only patients with a high performance status and those not having evidence of disease progression following chemoradiotherapy were enrolled.
Finally, it should be noted the effect of anaemia was detected in the groups with optimal criteria for response, for example, high performance status and high drug intensity, but with less active regimens or iller patients no effect was seen.
The presence of an ascitis (P=0.03), a high performance status (P=0.03) and HER-2 overexpression (P=0.03) were significantly associated with shorter overall survival.
Among binary prognostic factors, smoking (ever vs never), higher baseline cancer stage (IIIB+pleural effusion vs IIIA/IIIB), and type of chemotherapy regimen (single- vs double-agent regimen) were all independently associated with significantly higher mortality, while higher performance status (ECOG 2 vs 0 1) showed a trend toward worse prognosis (P=0.086).
Higher performance status correlated with elevated baseline VEGF and VHL mutations, whereas higher risk grouping correlated with elevated VEGF, CAIX and TIMP-1.
Also a higher performance status (higher Karnofsky index) has shown association with insomnia measured with the single question in the multivariate regression analysis of this study.
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