These data show that this effort pays off with high necessity-concern scores.
Higher numbers of clinical complications were associated with higher necessity of DFO and higher Sensitive Soma score.
8 Multiple studies have demonstrated that better adherence is associated with higher necessity beliefs and fewer concerns about treatment.
Consistent with the development of the scales [ 2], high necessity and concerns were defined as scores above the midpoint, and four groups were defined: accepting (high necessity, low concerns), ambivalent (high necessity, high concerns), indifferent (low necessity, low concerns), and skeptical (low necessity, high concerns) [ 11].
Of those on transfusion therapy, 96% reported high necessity (> midpoint of 15 points), with 48% reporting high concerns.
Patients expressed high "necessity" for transfusion (96%), DFO chelation (92%) and oral chelation (89%), with lower "concern" about treatment (48%, 39 %, 19 respectively).
Therefore, a further investigation is of high necessity to assert.
Views about DFO and oral chelation, respectively, were 56%and73%3% accepting (high necessity, low concerns), 36% and 16% ambivalent (high necessity, high concerns), 5% and 8% indifferent (low necessity, low concerns), and 3% and 4% skeptical (low necessity, high concerns).
For chelation therapy, high necessity was reported in 92% of those on DFO and 89% of those on oral chelation, with concerns reported in 39%and19%9% respectively.
High ferritin iron levels, potentially indicating lower adherence, were found in 41% of patients reporting low necessity of oral chelation compared to 24% reporting high necessity (p=0.048).
