Analysis of pairs of compounds with high structure similarity revealed the presence of single-, duand, and 'pan-receptor' activity cliffs, that is, small changes in structure with high changes in potency for one, two, or three receptor subtypes, respectively.
Focusing the analysis on pairs of compounds with high structure similarity revealed the presence of single-, duand and triple-target activity cliffs, i.e., small changes in structure with high changes in potency for one, two or the three targets, respectively.
Moreover, they are the requirements to generate a more powerful local feature descriptor for multimodal images with high changes of content and a more efficient outlier rejection strategy with a local model fit to deal with the spherical geometry of the eyeball.
When discussing the obtained results, we should not forget that the research only included hospitals with high change-implementation goals, so the research should be conducted again in all Slovenian hospitals to establish the possible differences in middle-management capacity for the examined variables.
Higher baseline DAS28 was associated with higher change in DAS28 in response to therapy (see online supplementary figure S1C).
The patients with higher change of the CD8/FOXP3 ratio had significantly better RFS and BCSS compared with those not (P=0.011 and P=0.023, respectively).
Correlation analysis indicated that higher progesterone concentration was significantly associated with higher change in subjective fatigue ratings (r = 0.45, P = 0.02); that is, the progress of subjective fatigue increased with increasing progesterone.
Higher changes in capillary pressure are associated with higher changes in interfacial tensions.
Bartel and Sicherman (1993) (henceforth, BS) find that workers in industries with high technical change retire later than workers in industries with low technical change.
Exons with high splicing change (≥3 fold) were further analyzed with respect to their inclusion or exclusion (Fig. 1b).
