The authors suggested that genes with high expression breadth and high intron number will be more prone to produce new transcript isoforms which could be maintained because ensuring an higher adaptability to various tissues conditions.
These patterns form "cascades" with different profiles: for instance, a fast-spreading rumor that's quickly snuffed out would have high breadth but little depth, and low virality.
The 3D menu was preferred by users at high breadth levels, and the 2D menu showed better performance than the 3D menu with low memory load.
Massively parallel ('next generation') resequencing is potentially a powerful tool with which to study heteroplasmic mitochondrial DNA (mtDNA) mutations because of the possibility of the high breadth and depth of coverage.
For one immunogen, the neutralizing response was increased with a higher breadth compared to the Wild-Type.
Negative values, on the contrary, are related to phalanges with a flat appearance due to high breadths at midshaft and at the distal end (i.e. with apical tuberosities instead of tufts).
Expression breadth, however, shows a contrasting pattern, i.e. longer genes have higher breadth of expression, possibly to ensure those structural features associated with gene plasticity.
Namely, there is a strong depletion not only of "high rate/low breadth", but "high rate/medium to medium-high breadth" categories of sites and proteins.
To understand the relationship between transmembrane transport and tissue expression breadth on protein evolutionary rate, we split all the genes into three equally spaced bins according to their tissue expression breadth (bin 1: lower breadth [range: 1 7, n = 2,828], bin 2: medium breadth [range: 8 14, n = 1,444], and bin 3: higher breadth [range: 15 22, n = 2,783]).
We also found that gene size, CDS length, first intron length, average intron length, and total intron length showed significantly negative correlation with expression breadth with high regression coefficient (see Figure 3a-e).
