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As a well-known poor prognostic factor, PVTT markedly deteriorates the hepatic function and correlates with greater recurrence and intrahepatic metastasis (Li et al, 2009).
Hypoxia is a common characteristic of locally advanced solid tumors that has been associated with greater recurrence, less locoregional control, diminished therapeutic responses, and lower overall and disease-free survival [ 20, 21].
Allegra et al. [ 40] described inverse associations, with a lower rate of Ki-67 to be associated with greater recurrence and worse overall survival and Jansson and Sun [ 39] did not find any associations between index Ki-67 and clinicopathological data or prognosis.
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In addition, higher ROCK1 levels correlated with greater recurrence-free survival (p = 0.001).
This is an important issue when comparing two treatments because, while both may have a high 2-h PF rate, one may be associated with a greater recurrence between 2 and 24 h after dosing.
Such patients have been found to have longer duration of episodes and greater recurrence than those with nonpsychotic depression [ 28].
A positive value of coefficients indicated that larger values of the expression were associated with greater groin recurrence rates.
Age <45 years, >25% of nodes positive, medial tumour location and estrogen receptor (ER) negative (ER ve) status have been found to be statistically significant independent factors associated with greater local recurrence, meriting consideration and discussion of post-mastectomy RT (Truong et al., 2005).
Do they show greater recurrence risk of breast cancer?
This classification has some prognostic power with greater risk of recurrence being associated with high-nuclear grade; however, poor reproducibility limits the clinical value of this system.
Truong et al (2005b) also suggested that the percentage of node positive (>25% of removed nodes) were statistically significant independent factors associated with greater loco-regional recurrence, meriting consideration of PMRT in patients with pN1 and T1/T2 disease.
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