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Funabiki, M. et al. Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
We have previously demonstrated that MYO10 levels correlate with gain of function p53 mutations in human breast tumours, increased metastasis and poor prognosis.
Regarding cytogenetic abnormalities, high IKZF1, IKZF3, and KPNA2 expression were observed in hyperdiploid MM cells with gain of chromosomes 5, 9, 15, and 19.
Mixed gain (G3) was recorded in patients with gain of both thermal and mechanical somatosensory function.
In both cases, we considered omnidirectional antennas with gain of 2 dBi.
The most frequent loss/gain score encountered was L0G2 (no somatosensory loss combined with gain of mechanical somatosensory function).
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Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion channel.
A significant number of patients with gain-of-function mutations show severe epilepsy phenotypes considered more typical of deletion or frameshift mutations13,17,18.
Perrotta, S. et al. Congenital erythrocytosis associated with gain-of-function HIF2A gene mutations and erythropoietin levels in the normal range.
Southern blot analysis of segregating BC2F2 progeny of G978 × IR64 further confirmed that the polymorphism in AK102429 co-segregated with gain-of-resistance phenotype (Fig. 5b).
In conclusion, through systematic screening, we have identified a rare mutant with gain-of-resistance to blast and bacterial blight without serious pleiotropic effects.
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