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The complex nature of SLE with fluctuating levels of disease activity involving one or multiple organs, which may vary between patients and within the same patient over time, continues to challenge SLE investigators.
However, the similarities between the students with increasing and decreasing life satisfaction, and the differences between these and the ones with stable high life satisfaction, forced us to interpret these findings as indicating that there were really only two true subgroups; one with sustained high life satisfaction, and one with fluctuating levels.
With progression to PDD these deficits worsen, and impaired vigilance also develops with fluctuating levels of alertness (Ballard et al., 2002), which in turn drives fluctuating levels of cognition (Walker, 2000).
This is often the case for teenagers who are also struggling with fluctuating levels of hormones.
We therefore ran a second analysis with two clusters, and found a stable group (n = 149) and a group with fluctuating levels of life satisfaction (n = 87).
Compared to the group with fluctuating levels of life satisfaction, the stable students differed with respect to both perceived stress and coping abilities.
Similar(50)
And menstruation, with its accompanying fluctuating levels of the female sex hormone estrogen, can have a considerable effect on how a woman's body responds to the demands of exercise and competition, as a range of provocative new science makes clear.
The disorder resembles metabolic encephalopathies, with intact brainstem function, fluctuating levels of consciousness and diffuse cerebral dysfunction.
Basic research indicates a protective role for high levels of androgens in young males, with little role for fluctuating levels of ovarian hormones in females.
Children with persistently positive IAA levels had a higher progression rate to diabetes (100% by 5.6 years) than children with fluctuating IAA levels (63% by the 10-year follow-up) (P < 0.0001) (Fig. 1 B ).
We suspect that the low rate of dengue-immune adolescent participants may reflect the unique epidemiological profile of dengue disease within Singapore, a country with fluctuating endemicity levels that lie between the high endemicity seen in countries such as Vietnam and the lower levels found, for example, in the USA.
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