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Additional file 1: Algorithm for string-of-beads design with flexible spacer sequences.

In the following, we describe the prediction models used and derive the mathematical formulation to tackle the problem of designing a SBV with flexible spacer sequences.

We also extend the formulation to determine the optimal spacer length and combine this approach with that of Toussaint et al. [ 7] to design an optimal SBV with flexible spacer sequences.

With our molecular dynamics (MD) simulations conducted in 40% HFIP/60% water, the "100 nsec" models for monomeric MB and S-MB (Figs. 4B and 7B) indicated that each peptide is organized as a helical bundle in this membrane-interfacial environment, with S-MB having an additional flexible sequence (residues 1 7) projecting from its core.

Most fragile sites sequenced to date contain highly flexible sequences and AT-rich islands, with the potential to form secondary structures, which are significantly more stable than same-length random DNA sequences [ 17, 18].

The list is Python's most useful and flexible sequence type.

The second family has alternating, flexible sequences, such as (AT n, (AC n and related sequences.

Those given the flexible sequence thought the task would be easier than those who were given the fixed sequence.

Considering additional spacer sequences with flexible length, increases the possibilities many times over.

Owing to the unique brush-like microstructure of PP-OH, with flexible primary hydroxy groups and long sequences of propylene units, the hydroxy groups effectively form chemical bonds with the free silanol groups on the glass surface, and the PP segments cocrystallize with isotactic PP.

Methadone treatment was switched to SROM with flexible dosing and vice versa according to period and sequence of treatment.

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