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In short, they would make up money with faster turnover.
The lower observed steady state levels of the IRAK-M mutant protein with the modified D19-A23 stretch would be consistent with faster turnover through increased kinetics of activation and subsequent degradation events.
The encoded enzyme variants differ significantly in the ethanol concentrations they require for maximal function and in how fast they metabolize the ethanol (i.e., in their kinetic properties), with both ADH1B*2 and ADH1B*3 encoding enzymes with faster turnover (i.e., higher Vmax) than the reference allele (see table 1).
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As ever look for those with fast turnover and local customers.
The approach has been especially popular with fast turnover jobs in the service industry, such as hospitality and retail.
Next generation sequencing has revolutionized the field of biomedical research over the past decade, and while the leading sequencing platforms were initially tailored toward large-scale applications, recent technical improvements have led to the development of modestly priced benchtop instruments with fast turnover rates aimed at small-scale laboratories.
Since the changes of nucleo-cytoplasmic shuttling are controlled by the N-terminus of ERK1, we asked whether the deletion of this domain (E1Δ39), by providing ERK1 with a faster turnover would also convert ERK1 in a kinase functionally similar to ERK2.
The absence of available NF90 to bind the dengue 3'SL during an shRNA-mediated NF90 depletion experiment could correlate with a faster turnover of the dengue mRNA and account for decreased viral RNA and NS3 levels observed in the infected shDRBP76-GFP NF90 knockdown cells.
Kinetic studies were performed with the same substrates to support the superimposition analysis and the results show that all of these phenolic compounds are readily accepted as substrates, with significantly faster turnover for the monophenols lacking a carboxylate moiety.
Interestingly, both mutants recovered throughout the entire lamellipodium with even faster turnover rates than wild-type cofilin, indicating that phosphorylation/dephosphorylation events may retain the protein in the lamellipodium, but the TMF was virtually identical to the wild-type protein (see also Table I).
This classification incorporates the assumption that the elastin content is essentially constant over time (Tsamis et al. 2013), while other constituents have a substantially faster turnover, with a timescale of approximately 2 months (Nissen et al. 1978; Martufi and Gasser 2012).
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