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RNA interference (RNAi) offers an attractive means to silence gene expression with extraordinary specificity, particularly for the subset of candidate therapeutic gene targets that are considered "undruggable".
Another concept, the altered repertoire model, has recently been proposed, according to which the drugs or its metabolites can bind noncovalently within the pocket of the peptide binding groove of certain MHC molecules with extraordinary specificity, allowing a new repertoire of endogenous self-peptides to be bound and presented.
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Like the woman, the boys are modeled and painted with extraordinary anatomical specificity, but they also represent generic male types; they are titled, from left to right, "Divine Warrior," "Nkondi" (the name of a vengeful African mythic figure), "Holy Man" and "Ayatollah".
With respect to the action of the whole venom, the extraordinary specificity of the conopeptides indicates that every single peptide is a "specialist" optimized for a certain target and that only the concerted action of the different peptides present in the venom results in the biological action needed for the achievement of the predatory life of these snails.
Bacteria produce many enzymes that show extraordinary specificity for mammalian intracellular proteins.
The mechanisms by which molecular beacons are able to have extraordinary specificity are also presented.
Based on this extraordinary specificity of L-413C confirmed in our tests, we propose to use parallel qPCR assays with both phages for rapid and reliable detection and identification of Y. pestis.
As part of this process, the immune system is able to generate extraordinary specificity of antibodies to particular antigens.
These characteristics result in both an extraordinary specificity in pheromone communication, as well as the potential for huge diversity in pheromone blends [ 4].
They possess extraordinary specificity for a vast array of substrates and, as such, are considered promising, if challenging, targets for drug discovery [ 2].
Chips made by firms such as Archemix and Zyomyx are embedded with agents such as antibodies, antibody-mimics and aptamers (single strands of RNA or DNA which, like antibodies, can bind to target molecules with extraordinary affinity and specificity) to trap proteins and detect their quantities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com