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Sensitivity and specificity calculations across the expanded validation panel were consistent with those obtained from the initial panel.
The authors recognize that additional validations with expanded cohorts are necessary to determine whether these findings represent an H1N1-specific molecular signature or one that is more representative of influenza viruses or other respiratory pathogens [ 6].
Along with expanded acreage is expanded awareness.
Expanding bulk has not been matched with expanding variety.
This approach expanded the validation studies on TOEFL (Chapelle et al. 2008).
As the TCGA dataset is limited by its papillary histology-focused sample collection, whether somatic SDHB expressional differences could distinguish papillary from follicular histology needs further validation with an expanded sample size.
We also performed a pooled analysis for UBE2L3, expanding the validation cohort from the meta-analysis of Stahl et al 24 with the UK non-overlapping samples genotyped in our study, and including data from GWAS.
However, these criteria cannot be formally proposed for patients with type I cryoglobulinaemia, and the experts agreed that this patient subset should be expanded in subsequent validation studies.
Validation in expanded cohorts and mechanistic studies are needed to better understand the significance of these findings.
Tactical applications have expanded in breadth with field validation and experience, and precise navigation solutions for the new missions are being explored.
DAM participated in the model validation and expanded the scope of the study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com