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We show that the low number of spermatozoa and atrophied testis in male Sirt1 deficient mice is due to effects that manifest at least as early as d15.5 of development, and correspond with elevated frequency of DNA damage in mature sperm in adult mice.
The association with elevated frequency of ECFCs was modest in the patients who were females, younger than 50 years, or with the diagnosis of prefibrotic myelofibrosis, but was greater and highly statistically significant in patients who had a non-active disease, and was greatest in those who had a history of splanchnic vein thrombosis.
Human hypothermia (32°C) is associated with elevated frequency of infectious complications; dysfunction of the immune response caused by hypothermia has been demonstrated in both clinical and animal studies [ 31].
Furthermore, increased expression of genes belonging to the so-called interferon-related gene signature including STAT1 was shown to correlate with elevated frequency of relapse in human breast cancer [ 17].
Several studies have reported that exposure to POPs/PCBs is associated with elevated frequency of several chronic diseases, such as ischemic heart disease, diabetes, hypertension and chronic liver disease [ 9, 21, 22].
In fact, although aggressive titration of premixed insulin can lower A1C to target (33) or near-to-target (31), this result is associated with elevated frequency of hypoglycemia (31, 34) due to inappropriate pharmacokinetics and pharmacodynamics, primarily in the interprandial state of the late-morning and early-night hours (37).
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Obligate animal symbionts and pathogens display rapid evolution and have highly biased nucleotide base compositions with elevated frequencies of adenine and thymine (A+T) (reviewed in [ 29]).
Incompletely reprogrammed cells derived from neural stem cells or fibroblasts responded to Gcsf with elevated frequencies of progression to ground state pluripotency.
Consistent with elevated frequencies of Th17 cells, we also found that Th17-associated cytokines were increased in PB and BM of AML patients compared with those of healthy donors.
In this alternative paradigm, viruses with elevated frequencies of CpG and UpA are not intrinsically defective but they are more readily recognised by the cell and prevented from initiating replication.
Currently available reports have shown unequivocally that increased platelet activity is associated with an elevated frequency of vascular complications in adult patients with type 2 diabetes (T2DM) [ 4, 6].
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