In a 3+3+3 design, patients with advanced solid tumours received escalating doses of oral pazopanib combined with ifosfamide either given 3 days continuously or given 3-h bolus infusion daily for 3 days (9 g m−2 per cycle, every 3 weeks).
Trials with NGF for AD are ongoing, with the growth factor either given as infused protein [ 183], released in situ by implanted NGF-secreting cells [ 184] or adeno-associated gene delivery [ 185].
For a stuffed animal with the hiccups, either give him/her a drink of (fake) water or try to surprise them away, depending on which stuffed animal has the hiccups.
Someone with a hobby, either giving them a voucher to a specialty store or getting them to chat about the hobby and discuss the materials (and their preferences and future projects) can give very clear ideas and even set up for a surprise without the hobbyist realizing they've been questioned.
This leaves the Flemish independence movement with some stark choices: either give up Brussels, leave its current semi-autonomous status intact or "annex" it.
Kiev was faced with an unenviable choice: either give up another chunk of territory without a fight, as in Crimea, or fight a counter-insurgency campaign in urban areas that would likely lead to civilian deaths.
Not building, because it is really difficult to build something new in the U.S. We are looking for partnership arrangements with refineries partners that would either give us access to their refinement capabilities.
He noticed that when the yacht met with bad weather, Truman would either give orders to turn around or he would get off and fly to his destination.
If you don't want to go out with him, then you could either give him a straight up no or say that you're going to think about it.
Randomised trials have demonstrated that the addition of platin-based chemotherapy to radiation is associated with a survival advantage when either given as induction (Sause et al, 1995; Dillman et al, 1996) or concurrent treatment (Schaake-Koning et al, 1992) compared to radiation alone.
