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Typically, irradiation-hardening rates are large, in the range 100 1000 GPa/dpa, at the lowest dose of <0.0001 dpa and decrease with dose to a few tens of MPa/dpa or less at about 10 dpa.
Higher preheats, up to 300 °C, preferentially removed OSL and TTOSL signals evident at longer stimulation times: those that remained yielded growth in signal with dose to approximately 10 kGy, but the accuracy of retrospective dose determinations was variable.
To overcome this limitation, one can reduce treatment volume to normal tissue or sculpt the target dose as an increment with dose to the tumor [ 2].
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Another apparently ineffective drug is oxcarbazepine which was tried for migraine prophylaxis in a relatively large RCDBT with doses to at least 1,200 mg/day [44].
It strongly decreases with increasing dose to approximately 4000 g/mol at a irradiation dose of 4 MGy.
The measurement results suggested that samples collected below 2500 m should be taken with double dose to ensure their efficacy.
In the high-dose region, cancer increased with radiation dose to a very high frequency.
The investigators were suggested to start with lower dose to improve tolerability and compliance towards medication.
Risk increased with increasing dose to the stomach tumour site P-trend<0.001 P-trend<0.0010.5 (95% CI 3.7–114.3) at ⩾50.0 Gy compareaching doses <10 Gy.
Dosing modifications were required in 15 patients (31.9%), including 14 patients (29.8%) with dose reductions to 25 mg and one patient with dose escalation to 50 mg (as permitted per protocol).
Fibres of higher draw ratio showed a sharper decrease in melting temperature with dose, ascribed to crosslinking at fold surfaces and greater chain scission, due to higher crystallinity.
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